DTX2
| Deltex 2, E3 ubiquitin ligase | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | DTX2 ; RNF58 | ||||||||||||
| External IDs | OMIM: 613141 MGI: 1921448 HomoloGene: 56904 GeneCards: DTX2 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 113878 | 74198 | |||||||||||
| Ensembl | ENSG00000091073 | ENSMUSG00000004947 | |||||||||||
| UniProt | Q86UW9 | Q8R3P2 | |||||||||||
| RefSeq (mRNA) | NM_001102594 | NM_001256096 | |||||||||||
| RefSeq (protein) | NP_001096064 | NP_001243025 | |||||||||||
| Location (UCSC) |
Chr 7: 76.46 – 76.51 Mb |
Chr 5: 135.99 – 136.03 Mb | |||||||||||
| PubMed search | |||||||||||||
Protein deltex-2 also known as E3 ubiquitin-protein ligase DTX2 is an enzyme that in humans is encoded by the DTX2 gene.[1]
DTX2 functions as a ubiquitin E3 ligase in conjunction with the E2 enzyme UBCH5A.[2]
References
- ↑ "Entrez Gene: DTX2 deltex homolog 2 (Drosophila)".
- ↑ Takeyama K, Aguiar RC, Gu L, He C, Freeman GJ, Kutok JL, Aster JC, Shipp MA (2003). "The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity". J. Biol. Chem. 278 (24): 21930–7. doi:10.1074/jbc.M301157200. PMID 12670957.
Further reading
- Matsuno K, Diederich RJ, Go MJ, et al. (1995). "Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats". Development 121 (8): 2633–44. PMID 7671825.
- Kishi N, Tang Z, Maeda Y, et al. (2001). "Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis". Int. J. Dev. Neurosci. 19 (1): 21–35. doi:10.1016/S0736-5748(00)00071-X. PMID 11226752.
- Yamamoto N, Yamamoto S, Inagaki F, et al. (2002). "Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor". J. Biol. Chem. 276 (48): 45031–40. doi:10.1074/jbc.M105245200. PMID 11564735.
- Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell Proteomics 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
- Hiller M, Huse K, Szafranski K, et al. (2007). "Single-nucleotide polymorphisms in NAGNAG acceptors are highly predictive for variations of alternative splicing". Am. J. Hum. Genet. 78 (2): 291–302. doi:10.1086/500151. PMC 1380236. PMID 16400609.
- Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
- Yi Z, Yi T, Wu Z (2007). "cDNA cloning, characterization and expression analysis of DTX2, a human WWE and RING-finger gene, in human embryos". DNA Seq. 17 (3): 175–80. doi:10.1080/10425170600857616. PMID 17286044.
External links
- DTX2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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