IRF9
| Interferon regulatory factor 9 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | IRF9 ; IRF-9; ISGF3; ISGF3G; p48 | ||||||||||||
| External IDs | OMIM: 147574 MGI: 107587 HomoloGene: 4436 GeneCards: IRF9 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 10379 | 16391 | |||||||||||
| Ensembl | ENSG00000213928 | ENSMUSG00000002325 | |||||||||||
| UniProt | Q00978 | Q61179 | |||||||||||
| RefSeq (mRNA) | NM_006084 | NM_001159417 | |||||||||||
| RefSeq (protein) | NP_006075 | NP_001152889 | |||||||||||
| Location (UCSC) |
Chr 14: 24.16 – 24.17 Mb |
Chr 14: 55.6 – 55.61 Mb | |||||||||||
| PubMed search | |||||||||||||
Interferon regulatory factor 9 is a protein that in humans is encoded by the IRF9 gene, previously known as ISGF3G.[1][2][3]
Interactions
IRF9 has been shown to interact with STAT2[4][5] and STAT1.[4]
References
- ↑ Veals SA, Schindler C, Leonard D, Fu XY, Aebersold R, Darnell JE Jr, Levy DE (Aug 1992). "Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins". Mol Cell Biol 12 (8): 3315–24. PMC 364572. PMID 1630447.
- ↑ McCusker D, Wilson M, Trowsdale J (Jun 1999). "Organization of the genes encoding the human proteasome activators PA28alpha and beta". Immunogenetics 49 (5): 438–45. doi:10.1007/s002510050517. PMID 10199920.
- ↑ "Entrez Gene: ISGF3G interferon-stimulated transcription factor 3, gamma 48kDa".
- 1 2 Horvath, C M; Stark G R; Kerr I M; Darnell J E (Dec 1996). "Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex". Mol. Cell. Biol. (UNITED STATES) 16 (12): 6957–64. ISSN 0270-7306. PMC 231699. PMID 8943351.
- ↑ Martinez-Moczygemba, M; Gutch M J; French D L; Reich N C (Aug 1997). "Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3". J. Biol. Chem. (UNITED STATES) 272 (32): 20070–6. doi:10.1074/jbc.272.32.20070. ISSN 0021-9258. PMID 9242679.
Further reading
- Cebulla CM, Miller DM, Sedmak DD (2000). "Viral inhibition of interferon signal transduction". Intervirology 42 (5–6): 325–30. doi:10.1159/000053968. PMID 10702714.
- Reich NC (2002). "Nuclear/cytoplasmic localization of IRFs in response to viral infection or interferon stimulation". J. Interferon Cytokine Res. 22 (1): 103–9. doi:10.1089/107999002753452719. PMID 11846981.
- Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
- David M, Romero G, Zhang ZY, et al. (1993). "In vitro activation of the transcription factor ISGF3 by interferon alpha involves a membrane-associated tyrosine phosphatase and tyrosine kinase". J. Biol. Chem. 268 (9): 6593–9. PMID 8454630.
- Horvath CM, Stark GR, Kerr IM, Darnell JE (1997). "Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex". Mol. Cell. Biol. 16 (12): 6957–64. PMC 231699. PMID 8943351.
- Martinez-Moczygemba M, Gutch MJ, French DL, Reich NC (1997). "Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3". J. Biol. Chem. 272 (32): 20070–6. doi:10.1074/jbc.272.32.20070. PMID 9242679.
- Reddy PH, Stockburger E, Gillevet P, Tagle DA (1998). "Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method". Genomics 46 (2): 174–82. doi:10.1006/geno.1997.5044. PMID 9417904.
- Lau JF, Parisien JP, Horvath CM (2000). "Interferon regulatory factor subcellular localization is determined by a bipartite nuclear localization signal in the DNA-binding domain and interaction with cytoplasmic retention factors". Proc. Natl. Acad. Sci. U.S.A. 97 (13): 7278–83. doi:10.1073/pnas.97.13.7278. PMC 16536. PMID 10860992.
- Nehyba J, Hrdlicková R, Burnside J, Bose HR (2002). "A Novel Interferon Regulatory Factor (IRF), IRF-10, Has a Unique Role in Immune Defense and Is Induced by the v-Rel Oncoprotein". Mol. Cell. Biol. 22 (11): 3942–57. doi:10.1128/MCB.22.11.3942-3957.2002. PMC 133824. PMID 11997525.
- Chawla-Sarkar M, Leaman DW, Jacobs BS, et al. (2002). "Resistance to interferons in melanoma cells does not correlate with the expression or activation of signal transducer and activator of transcription 1 (Stat1)". J. Interferon Cytokine Res. 22 (5): 603–13. doi:10.1089/10799900252982089. PMID 12060499.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Lau JF, Nusinzon I, Burakov D, et al. (2003). "Role of Metazoan Mediator Proteins in Interferon-Responsive Transcription". Mol. Cell. Biol. 23 (2): 620–8. doi:10.1128/MCB.23.2.620-628.2003. PMC 151539. PMID 12509459.
- Jikuya H, Takano J, Kikuno R, et al. (2003). "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones". DNA Res. 10 (1): 49–57. doi:10.1093/dnares/10.1.49. PMID 12693554.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Thompson HG, Harris JW, Lin L, Brody JP (2004). "Identification of the protein Zibra, its genomic organization, regulation, and expression in breast cancer cells". Exp. Cell Res. 295 (2): 448–59. doi:10.1016/j.yexcr.2004.01.019. PMID 15093743.
- Sakamoto S, Potla R, Larner AC (2004). "Histone deacetylase activity is required to recruit RNA polymerase II to the promoters of selected interferon-stimulated early response genes". J. Biol. Chem. 279 (39): 40362–7. doi:10.1074/jbc.M406400200. PMID 15194680.
External links
- ISGF3G protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
- IRF9 human gene location in the UCSC Genome Browser.
- IRF9 human gene details in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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