NFX1

Nuclear transcription factor, X-box binding 1
Identifiers
Symbols	NFX1 ; NFX2; TEG-42; Tex42
External IDs	OMIM: 603255 MGI: 1921414 HomoloGene: 1875 GeneCards: NFX1 Gene
EC number	6.3.2.-
Gene ontology Molecular function • RNA polymerase II regulatory region sequence-specific DNA binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcription factor activity, sequence-specific DNA binding • zinc ion binding • ligase activity • poly(A) RNA binding Cellular component • nucleus • nucleoplasm • cytoplasm • plasma membrane Biological process • negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • inflammatory response • viral process • negative regulation of MHC class II biosynthetic process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4799	74164
Ensembl	ENSG00000086102	ENSMUSG00000028423
UniProt	Q12986	B1AY10
RefSeq (mRNA)	NM_002504	NM_001290448
RefSeq (protein)	NP_002495	NP_001277377
Location (UCSC)	Chr 9: 33.29 – 33.37 Mb	Chr 4: 40.97 – 41.03 Mb
PubMed search

Transcriptional repressor NF-X1 is a protein that in humans is encoded by the NFX1 gene.^[1][2][3]

MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-γ. Three alternative splice variants, each of which encodes a different isoform, have been identified.^[4]

References

1. Song Z, Krishna S, Thanos D, Strominger JL, Ono SJ (Dec 1994). "A novel cysteine-rich sequence-specific DNA-binding protein interacts with the conserved X-box motif of the human major histocompatibility complex class II genes via a repeated Cys-His domain and functions as a transcriptional repressor". J Exp Med 180 (5): 1763–74. doi:10.1084/jem.180.5.1763. PMC 2191754. PMID 7964459.
2. Hume CR, Lee JS (Jan 1990). "Congenital immunodeficiencies associated with absence of HLA class II antigens on lymphocytes result from distinct mutations in trans-acting factors". Hum Immunol 26 (4): 288–309. doi:10.1016/0198-8859(89)90007-4. PMID 2511169.
3. Arlotta P, Miyazaki D, Copeland NG, Gilbert DJ, Jenkins NA, Ono SJ (June 2002). "Murine NFX.1: isolation and characterization of its messenger RNA, mapping of its chromosomal location and assessment of its developmental expression". Immunology 106 (2): 173–81. doi:10.1046/j.1365-2567.2002.01416.x. PMC 1782705. PMID 12047746.
4. "Entrez Gene: NFX1 nuclear transcription factor, X-box binding 1".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Lorick KL, Jensen JP, Fang S, et al. (1999). "RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11364–9. doi:10.1073/pnas.96.20.11364. PMC 18039. PMID 10500182.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Saito K, Fujiwara T, Katahira J, et al. (2004). "TAP/NXF1, the primary mRNA export receptor, specifically interacts with a neuronal RNA-binding protein HuD". Biochem. Biophys. Res. Commun. 321 (2): 291–7. doi:10.1016/j.bbrc.2004.06.140. PMID 15358174.
• Gewin L, Myers H, Kiyono T, Galloway DA (2004). "Identification of a novel telomerase repressor that interacts with the human papillomavirus type-16 E6/E6-AP complex". Genes Dev. 18 (18): 2269–82. doi:10.1101/gad.1214704. PMC 517520. PMID 15371341.
• Katzenellenbogen RA, Egelkrout EM, Vliet-Gregg P, et al. (2007). "NFX1-123 and poly(A) binding proteins synergistically augment activation of telomerase in human papillomavirus type 16 E6-expressing cells". J. Virol. 81 (8): 3786–96. doi:10.1128/JVI.02007-06. PMC 1866132. PMID 17267499.

External links

• NFX1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)