NEUROD1

Neuronal differentiation 1
Identifiers
Symbols	NEUROD1 ; BETA2; BHF-1; MODY6; NEUROD; bHLHa3
External IDs	OMIM: 601724 MGI: 1339708 HomoloGene: 1871 GeneCards: NEUROD1 Gene
Gene ontology Molecular function • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • RNA polymerase II activating transcription factor binding • RNA polymerase II transcription coactivator activity • chromatin binding • double-stranded DNA binding • transcription factor activity, sequence-specific DNA binding • transcription coactivator activity • protein binding • transcription factor binding • sequence-specific DNA binding • protein heterodimerization activity • E-box binding Cellular component • nucleus • nucleoplasm • cytoplasm • RNA polymerase II transcription factor complex Biological process • pancreatic A cell fate commitment • pancreatic PP cell fate commitment • transcription from RNA polymerase II promoter • nucleocytoplasmic transport • nitric oxide mediated signal transduction • response to glucose • anterior/posterior pattern specification • dentate gyrus development • cerebellum development • neurogenesis • signal transduction involved in regulation of gene expression • insulin secretion • endocrine pancreas development • amacrine cell differentiation • enteroendocrine cell differentiation • response to drug • glucose homeostasis • positive regulation of apoptotic process • positive regulation of cell differentiation • positive regulation of neuron differentiation • positive regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • negative regulation of JAK-STAT cascade • embryonic organ morphogenesis • inner ear development • regulation of insulin secretion • positive regulation of sequence-specific DNA binding transcription factor activity • regulation of intestinal epithelial structure maintenance • regulation of cell cycle arrest • cellular response to glucose stimulus • negative regulation of type B pancreatic cell apoptotic process • positive regulation of transcription regulatory region DNA binding Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4760	18012
Ensembl	ENSG00000162992	ENSMUSG00000034701
UniProt	Q13562	Q60867
RefSeq (mRNA)	NM_002500	NM_010894
RefSeq (protein)	NP_002491	NP_035024
Location (UCSC)	Chr 2: 181.67 – 181.68 Mb	Chr 2: 79.45 – 79.46 Mb
PubMed search

Neurogenic differentiation 1 (NeuroD1), also called β2,^[1] is a transcription factor of the NeuroD-type. It is encoded by the human gene NEUROD1.

It is a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene, and mutations in this gene result in type II diabetes mellitus.^[2]

Interactions

NEUROD1 has been shown to interact with MAP3K10,^[3] MAFA^[4] and Cyclin D1.^[5]

References

1. Poulin G, Turgeon B, Drouin J (Nov 1997). "NeuroD1/beta2 contributes to cell-specific transcription of the proopiomelanocortin gene". Molecular and Cellular Biology 17 (11): 6673–82. doi:10.1128/mcb.17.11.6673. PMC 232521. PMID 9343431.
2. "Entrez Gene: NEUROD1 neurogenic differentiation 1".
3. Marcora E, Gowan K, Lee JE (Aug 2003). "Stimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2". Proceedings of the National Academy of Sciences of the United States of America 100 (16): 9578–83. doi:10.1073/pnas.1133382100. PMC 170960. PMID 12881483.
4. Zhao L, Guo M, Matsuoka TA, Hagman DK, Parazzoli SD, Poitout V, Stein R (Mar 2005). "The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription". The Journal of Biological Chemistry 280 (12): 11887–94. doi:10.1074/jbc.M409475200. PMID 15665000.
5. Ratineau C, Petry MW, Mutoh H, Leiter AB (Mar 2002). "Cyclin D1 represses the basic helix-loop-helix transcription factor, BETA2/NeuroD". The Journal of Biological Chemistry 277 (11): 8847–53. doi:10.1074/jbc.M110747200. PMID 11788592.

Further reading

• Fajans SS, Bell GI, Polonsky KS (Sep 2001). "Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young". The New England Journal of Medicine 345 (13): 971–80. doi:10.1056/NEJMra002168. PMID 11575290.
• Cho JH, Tsai MJ (Aug 2004). "The role of BETA2/NeuroD1 in the development of the nervous system". Molecular Neurobiology 30 (1): 35–47. doi:10.1385/MN:30:1:035. PMID 15247487.
• Chae JH, Stein GH, Lee JE (Dec 2004). "NeuroD: the predicted and the surprising". Molecules and Cells 18 (3): 271–88. PMID 15650322.
• Tamimi R, Steingrimsson E, Copeland NG, Dyer-Montgomery K, Lee JE, Hernandez R, Jenkins NA, Tapscott SJ (Jun 1996). "The NEUROD gene maps to human chromosome 2q32 and mouse chromosome 2". Genomics 34 (3): 418–21. doi:10.1006/geno.1996.0306. PMID 8786144.
• Yokoyama M, Nishi Y, Miyamoto Y, Nakamura M, Akiyama K, Matsubara K, Okubo K (Nov 1996). "Molecular cloning of a human neuroD from a neuroblastoma cell line specifically expressed in the fetal brain and adult cerebellum". Brain Research. Molecular Brain Research 42 (1): 135–9. doi:10.1016/S0169-328X(96)00154-4. PMID 8915591.
• Yokoyama M, Nishi Y, Yoshii J, Okubo K, Matsubara K (Oct 1996). "Identification and cloning of neuroblastoma-specific and nerve tissue-specific genes through compiled expression profiles". DNA Research 3 (5): 311–20. doi:10.1093/dnares/3.5.311. PMID 9039501.
• Acharya HR, Dooley CM, Thoreson WB, Ahmad I (Apr 1997). "cDNA cloning and expression analysis of NeuroD mRNA in human retina". Biochemical and Biophysical Research Communications 233 (2): 459–63. doi:10.1006/bbrc.1997.6483. PMID 9144558.
• Poulin G, Turgeon B, Drouin J (Nov 1997). "NeuroD1/beta2 contributes to cell-specific transcription of the proopiomelanocortin gene". Molecular and Cellular Biology 17 (11): 6673–82. doi:10.1128/mcb.17.11.6673. PMC 232521. PMID 9343431.
• Furuta H, Horikawa Y, Iwasaki N, Hara M, Sussel L, Le Beau MM, Davis EM, Ogata M, Iwamoto Y, German MS, Bell GI (Aug 1998). "Beta-cell transcription factors and diabetes: mutations in the coding region of the BETA2/NeuroD1 (NEUROD1) and Nkx2.2 (NKX2B) genes are not associated with maturity-onset diabetes of the young in Japanese". Diabetes 47 (8): 1356–8. doi:10.2337/diabetes.47.8.1356. PMID 9703340.
• Yoon YS, Noma T, Yamashiro Y, Ito H, Nakazawa A (Jul 1998). "Molecular cloning and characterization of the gene encoding human NeuroD". Neuroscience Letters 251 (1): 17–20. doi:10.1016/S0304-3940(98)00490-X. PMID 9714454.
• Miyachi T, Maruyama H, Kitamura T, Nakamura S, Kawakami H (Jun 1999). "Structure and regulation of the human NeuroD (BETA2/BHF1) gene". Brain Research. Molecular Brain Research 69 (2): 223–31. doi:10.1016/S0169-328X(99)00112-6. PMID 10366743.
• Noma T, Yoon YS, Yamashiro Y, Fujisawa K, Nakazawa A (Sep 1999). "Regulation of NeuroD expression by activation of the protein kinase-C pathway in Y79 human retinoblastoma cells". Neuroscience Letters 272 (1): 45–8. doi:10.1016/S0304-3940(99)00569-8. PMID 10507539.
• Malecki MT, Jhala US, Antonellis A, Fields L, Doria A, Orban T, Saad M, Warram JH, Montminy M, Krolewski AS (Nov 1999). "Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus". Nature Genetics 23 (3): 323–8. doi:10.1038/15500. PMID 10545951.
• Glick E, Leshkowitz D, Walker MD (Jan 2000). "Transcription factor BETA2 acts cooperatively with E2A and PDX1 to activate the insulin gene promoter". The Journal of Biological Chemistry 275 (3): 2199–204. doi:10.1074/jbc.275.3.2199. PMID 10636926.
• Onions J, Hermann S, Grundström T (Apr 2000). "A novel type of calmodulin interaction in the inhibition of basic helix-loop-helix transcription factors". Biochemistry 39 (15): 4366–74. doi:10.1021/bi992533u. PMID 10757985.
• Mochizuki M, Amemiya S, Kobayashi K, Kobayashi K, Ishihara T, Aya M, Kato K, Kasuga A, Nakazawa S (Jan 2002). "The association of Ala45Thr polymorphism in NeuroD with child-onset Type 1a diabetes in Japanese". Diabetes Research and Clinical Practice 55 (1): 11–7. doi:10.1016/S0168-8227(01)00242-X. PMID 11755474.
• Ratineau C, Petry MW, Mutoh H, Leiter AB (Mar 2002). "Cyclin D1 represses the basic helix-loop-helix transcription factor, BETA2/NeuroD". The Journal of Biological Chemistry 277 (11): 8847–53. doi:10.1074/jbc.M110747200. PMID 11788592.
• Westerman BA, Poutsma A, Maruyama K, Schrijnemakers HF, van Wijk IJ, Oudejans CB (Apr 2002). "The proneural genes NEUROD1 and NEUROD2 are expressed during human trophoblast invasion". Mechanisms of Development 113 (1): 85–90. doi:10.1016/S0925-4773(01)00665-7. PMID 11900979.
• Kanatsuka A, Tokuyama Y, Nozaki O, Matsui K, Egashira T (Sep 2002). "Beta-cell dysfunction in late-onset diabetic subjects carrying homozygous mutation in transcription factors NeuroD1 and Pax4". Metabolism 51 (9): 1161–5. doi:10.1053/meta.2002.34707. PMID 12200761.

External links

• NEUROD1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.