PKNOX1

PBX/knotted 1 homeobox 1
PDB rendering based on 1x2n.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1X2N​
Identifiers
Symbols	PKNOX1 ; PREP1; pkonx1c
External IDs	OMIM: 602100 MGI: 1201409 HomoloGene: 3363 GeneCards: PKNOX1 Gene
Gene ontology Molecular function • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • transcription factor activity, sequence-specific DNA binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • sequence-specific DNA binding • protein heterodimerization activity Cellular component • nucleus • transcription factor complex • cytoplasm Biological process • angiogenesis • transcription from RNA polymerase II promoter • T cell differentiation • erythrocyte differentiation • camera-type eye development • positive regulation of transcription from RNA polymerase II promoter Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5316	18771
Ensembl	ENSG00000160199	ENSMUSG00000006705
UniProt	P55347	O70477
RefSeq (mRNA)	NM_001286258	NM_016670
RefSeq (protein)	NP_001273187	NP_057879
Location (UCSC)	Chr 21: 42.97 – 43.03 Mb	Chr 17: 31.56 – 31.61 Mb
PubMed search

Homeobox protein PKNOX1 is a protein that in humans is encoded by the PKNOX1 gene.^[1][2]

References

1. Berthelsen J, Viggiano L, Schulz H, Ferretti E, Consalez GG, Rocchi M, Blasi F (Apr 1998). "PKNOX1, a gene encoding PREP1, a new regulator of Pbx activity, maps on human chromosome 21q22.3 and murine chromosome 17B/C". Genomics 47 (2): 323–4. doi:10.1006/geno.1997.5086. PMID 9479508.
2. "Entrez Gene: PKNOX1 PBX/knotted 1 homeobox 1".

Further reading

• Allen TD, Zhu YX, Hawley TS, Hawley RG (2001). "TALE homeoproteins as HOX11-interacting partners in T-cell leukemia". Leuk. Lymphoma 39 (3–4): 241–56. doi:10.3109/10428190009065824. PMID 11342305.
• Chang CP, Shen WF, Rozenfeld S, et al. (1995). "Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins". Genes Dev. 9 (6): 663–74. doi:10.1101/gad.9.6.663. PMID 7729685.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
• Phelan ML, Featherstone MS (1997). "Distinct HOX N-terminal arm residues are responsible for specificity of DNA recognition by HOX monomers and HOX.PBX heterodimers". J. Biol. Chem. 272 (13): 8635–43. doi:10.1074/jbc.272.13.8635. PMID 9079695.
• Chen H, Rossier C, Nakamura Y, et al. (1997). "Cloning of a novel homeobox-containing gene, PKNOX1, and mapping to human chromosome 21q22.3". Genomics 41 (2): 193–200. doi:10.1006/geno.1997.4632. PMID 9143494.
• LeBrun DP, Matthews BP, Feldman BJ, Cleary ML (1997). "The chimeric oncoproteins E2A-PBX1 and E2A-HLF are concentrated within spherical nuclear domains". Oncogene 15 (17): 2059–67. doi:10.1038/sj.onc.1201367. PMID 9366523.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Berthelsen J, Zappavigna V, Mavilio F, Blasi F (1998). "Prep1, a novel functional partner of Pbx proteins". EMBO J. 17 (5): 1423–33. doi:10.1093/emboj/17.5.1423. PMC 1170490. PMID 9482739.
• Berthelsen J, Zappavigna V, Ferretti E, et al. (1998). "The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity". EMBO J. 17 (5): 1434–45. doi:10.1093/emboj/17.5.1434. PMC 1170491. PMID 9482740.
• Green NC, Rambaldi I, Teakles J, Featherstone MS (1998). "A conserved C-terminal domain in PBX increases DNA binding by the PBX homeodomain and is not a primary site of contact for the YPWM motif of HOXA1". J. Biol. Chem. 273 (21): 13273–9. doi:10.1074/jbc.273.21.13273. PMID 9582372.
• Berthelsen J, Kilstrup-Nielsen C, Blasi F, et al. (1999). "The subcellular localization of PBX1 and EXD proteins depends on nuclear import and export signals and is modulated by association with PREP1 and HTH". Genes Dev. 13 (8): 946–53. doi:10.1101/gad.13.8.946. PMC 316640. PMID 10215622.
• Jacobs Y, Schnabel CA, Cleary ML (1999). "Trimeric Association of Hox and TALE Homeodomain Proteins Mediates Hoxb2 Hindbrain Enhancer Activity". Mol. Cell. Biol. 19 (7): 5134–42. PMC 84356. PMID 10373562.
• Knoepfler PS, Bergstrom DA, Uetsuki T, et al. (1999). "A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1". Nucleic Acids Res. 27 (18): 3752–61. doi:10.1093/nar/27.18.3752. PMC 148632. PMID 10471746.
• Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.
• Kömüves LG, Shen WF, Kwong A, et al. (2000). "Changes in HOXB6 homeodomain protein structure and localization during human epidermal development and differentiation". Dev. Dyn. 218 (4): 636–47. doi:10.1002/1097-0177(2000)9999:9999<::AID-DVDY1014>3.0.CO;2-I. PMID 10906782.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Okada Y, Matsuura E, Nagai R, et al. (2003). "PREP1, MEIS1 homolog protein, regulates PF4 gene expression". Biochem. Biophys. Res. Commun. 305 (1): 155–9. doi:10.1016/S0006-291X(03)00718-6. PMID 12732210.

External links

• PKNOX1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.