PRDM2

PR domain containing 2, with ZNF domain

Rendering based on PDB 2JV0​.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PRDM2 ; HUMHOXY1; KMT8; MTB-ZF; RIZ; RIZ1; RIZ2
External IDs OMIM: 601196 MGI: 107628 HomoloGene: 40822 GeneCards: PRDM2 Gene
EC number 2.1.1.43
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 7799 110593
Ensembl ENSG00000116731 ENSMUSG00000057637
UniProt Q13029 A2A7B5
RefSeq (mRNA) NM_001007257 NM_001081355
RefSeq (protein) NP_001007258 NP_001074824
Location (UCSC) Chr 1:
13.7 – 13.83 Mb		 Chr 4:
143.11 – 143.21 Mb
PubMed search

PR domain zinc finger protein 2 is a protein that in humans is encoded by the PRDM2 gene.[1][2]

Function

This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Three transcript variants encoding different isoforms have been found for this gene.[2]

Interactions

PRDM2 has been shown to interact with Estrogen receptor alpha[3] and Retinoblastoma protein.[1]

References

  1. 1 2 Buyse IM, Shao G, Huang S (May 1995). "The retinoblastoma protein binds to RIZ, a zinc-finger protein that shares an epitope with the adenovirus E1A protein". Proceedings of the National Academy of Sciences of the United States of America 92 (10): 4467–71. doi:10.1073/pnas.92.10.4467. PMC 41965. PMID 7538672.
  2. 1 2 "Entrez Gene: PRDM2 PR domain containing 2, with ZNF domain".
  3. ↑ Abbondanza C, Medici N, Nigro V, Rossi V, Gallo L, Piluso G, Belsito A, Roscigno A, Bontempo P, Puca AA, Molinari AM, Moncharmont B, Puca GA (Mar 2000). "The retinoblastoma-interacting zinc-finger protein RIZ is a downstream effector of estrogen action". Proceedings of the National Academy of Sciences of the United States of America 97 (7): 3130–5. doi:10.1073/pnas.050015697. PMC 16204. PMID 10706618.

Further reading

  • Shapiro VS, Lee P, Winoto A (Oct 1995). "Identification and cloning of the G3B cDNA encoding a 3' segment of a protein binding to GATA-3". Gene 163 (2): 329–30. doi:10.1016/0378-1119(95)00420-B. PMID 7590293. 
  • Muraosa Y, Takahashi K, Yoshizawa M, Shibahara S (Feb 1996). "cDNA cloning of a novel protein containing two zinc-finger domains that may function as a transcription factor for the human heme-oxygenase-1 gene". European Journal of Biochemistry / FEBS 235 (3): 471–9. doi:10.1111/j.1432-1033.1996.00471.x. PMID 8654390. 
  • Buyse IM, Takahashi EI, Huang S (May 1996). "Physical mapping of the retinoblastoma interacting zinc finger gene RIZ to D1S228 on chromosome 1p36". Genomics 34 (1): 119–21. doi:10.1006/geno.1996.0249. PMID 8661032. 
  • Liu L, Shao G, Steele-Perkins G, Huang S (Jan 1997). "The retinoblastoma interacting zinc finger gene RIZ produces a PR domain-lacking product through an internal promoter". The Journal of Biological Chemistry 272 (5): 2984–91. doi:10.1074/jbc.272.5.2984. PMID 9006946. 
  • Xie M, Shao G, Buyse IM, Huang S (Oct 1997). "Transcriptional repression mediated by the PR domain zinc finger gene RIZ". The Journal of Biological Chemistry 272 (42): 26360–6. doi:10.1074/jbc.272.42.26360. PMID 9334209. 
  • He L, Yu JX, Liu L, Buyse IM, Wang MS, Yang QC, Nakagawara A, Brodeur GM, Shi YE, Huang S (Oct 1998). "RIZ1, but not the alternative RIZ2 product of the same gene, is underexpressed in breast cancer, and forced RIZ1 expression causes G2-M cell cycle arrest and/or apoptosis". Cancer Research 58 (19): 4238–44. PMID 9766644. 
  • Abbondanza C, Medici N, Nigro V, Rossi V, Gallo L, Piluso G, Belsito A, Roscigno A, Bontempo P, Puca AA, Molinari AM, Moncharmont B, Puca GA (Mar 2000). "The retinoblastoma-interacting zinc-finger protein RIZ is a downstream effector of estrogen action". Proceedings of the National Academy of Sciences of the United States of America 97 (7): 3130–5. doi:10.1073/pnas.050015697. PMC 16204. PMID 10706618. 
  • Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (Mar 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800. 
  • Du Y, Carling T, Fang W, Piao Z, Sheu JC, Huang S (Nov 2001). "Hypermethylation in human cancers of the RIZ1 tumor suppressor gene, a member of a histone/protein methyltransferase superfamily". Cancer Research 61 (22): 8094–9. PMID 11719434. 
  • Sasaki O, Meguro K, Tohmiya Y, Funato T, Shibahara S, Sasaki T (Mar 2002). "Nucleotide alteration of retinoblastoma protein-interacting zinc finger gene, RIZ, in human leukemia". The Tohoku Journal of Experimental Medicine 196 (3): 193–201. doi:10.1620/tjem.196.193. PMID 12002276. 
  • Poetsch M, Dittberner T, Woenckhaus C (May 2002). "Frameshift mutations of RIZ, but no point mutations in RIZ1 exons in malignant melanomas with deletions in 1p36". Oncogene 21 (19): 3038–42. doi:10.1038/sj.onc.1205457. PMID 12082534. 
  • Sasaki O, Meguro K, Tohmiya Y, Funato T, Shibahara S, Sasaki T (Dec 2002). "Altered expression of retinoblastoma protein-interacting zinc finger gene, RIZ, in human leukaemia". British Journal of Haematology 119 (4): 940–8. doi:10.1046/j.1365-2141.2002.03972.x. PMID 12472571. 
  • Tokumaru Y, Nomoto S, Jerónimo C, Henrique R, Harden S, Trink B, Sidransky D (Oct 2003). "Biallelic inactivation of the RIZ1 gene in human gastric cancer". Oncogene 22 (44): 6954–8. doi:10.1038/sj.onc.1206403. PMID 14534544. 
  • Kim KC, Geng L, Huang S (Nov 2003). "Inactivation of a histone methyltransferase by mutations in human cancers". Cancer Research 63 (22): 7619–23. PMID 14633678. 
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. 
  • Pan KF, Lu YY, Liu WG, Zhang L, You WC (Sep 2004). "Detection of frameshift mutations of RIZ in gastric cancers with microsatellite instability". World Journal of Gastroenterology 10 (18): 2719–22. PMID 15309726. 
  • Rossi M, Abbondanza C, D'Arcangelo A, Gazzerro P, Medici N, Moncharmont B, Puca GA (Nov 2004). "The Zn-finger domain of RIZ protein promotes MCF-7 cell proliferation". Cancer Letters 215 (2): 229–37. doi:10.1016/j.canlet.2004.05.014. PMID 15488642. 
  • Grundberg E, Carling T, Brändström H, Huang S, Ribom EL, Ljunggren O, Mallmin H, Kindmark A (Dec 2004). "A deletion polymorphism in the RIZ gene, a female sex steroid hormone receptor coactivator, exhibits decreased response to estrogen in vitro and associates with low bone mineral density in young Swedish women". The Journal of Clinical Endocrinology and Metabolism 89 (12): 6173–8. doi:10.1210/jc.2004-0403. PMID 15579774. 

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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