SOX15

SRY (sex determining region Y)-box 15
Identifiers
Symbols	SOX15 ; SOX20; SOX26; SOX27
External IDs	OMIM: 601297 MGI: 98363 HomoloGene: 74586 GeneCards: SOX15 Gene
Gene ontology Molecular function • RNA polymerase II transcription factor activity, sequence-specific DNA binding • DNA binding • chromatin binding • transcription factor activity, sequence-specific DNA binding • protein binding • protein heterodimerization activity Cellular component • nucleus • cytoplasm • nuclear transcription factor complex Biological process • negative regulation of transcription from RNA polymerase II promoter • chromatin organization • regulation of transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • male gonad development • positive regulation of satellite cell activation involved in skeletal muscle regeneration • cell differentiation • skeletal muscle tissue regeneration • negative regulation of striated muscle tissue development • positive regulation of transcription from RNA polymerase II promoter • myoblast development • positive regulation of G0 to G1 transition • positive regulation of myoblast proliferation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6665	20670
Ensembl	ENSG00000129194	ENSMUSG00000041287
UniProt	O60248	P43267
RefSeq (mRNA)	NM_006942	NM_009235
RefSeq (protein)	NP_008873	NP_033261
Location (UCSC)	Chr 17: 7.59 – 7.59 Mb	Chr 11: 69.66 – 69.66 Mb
PubMed search

Protein SOX-15 is a protein that in humans is encoded by the SOX15 gene.^[1][2][3]

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins.^[3]

See also

• SOX genes

References

1. Meyer J, Wirth J, Held M, Schempp W, Scherer G (Jan 1997). "SOX20, a new member of the SOX gene family, is located on chromosome 17p13". Cytogenet Cell Genet 72 (2-3): 246–9. doi:10.1159/000134200. PMID 8978787.
2. Critcher R, Stitson RN, Wade-Martins R, Easty DJ, Farr CJ (Oct 1998). "Assignment of Sox4 to mouse chromosome 13 bands A3-A5 by fluorescence in situ hybridization; refinement of the human SOX4 location to 6p22.3 and of SOX20 to chromosome 17p12.3". Cytogenet Cell Genet 81 (3-4): 294–5. doi:10.1159/000015052. PMID 9730625.
3. "Entrez Gene: SOX15 SRY (sex determining region Y)-box 15".

Further reading

• Wilson M, Koopman P (2003). "Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators.". Curr. Opin. Genet. Dev. 12 (4): 441–6. doi:10.1016/S0959-437X(02)00323-4. PMID 12100890.
• Schepers GE, Teasdale RD, Koopman P (2002). "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families.". Dev. Cell 3 (2): 167–70. doi:10.1016/S1534-5807(02)00223-X. PMID 12194848.
• Gozé C, Poulat F, Berta P (1993). "Partial cloning of SOX-11 and SOX-12, two new human SOX genes.". Nucleic Acids Res. 21 (12): 2943. doi:10.1093/nar/21.12.2943. PMC 309692. PMID 8332506.
• Hiraoka Y, Ogawa M, Sakai Y, et al. (1998). "Isolation and expression of a human SRY-related cDNA hSOX20.". Biochim. Biophys. Acta 1396 (2): 132–7. doi:10.1016/s0167-4781(97)00186-3. PMID 9540826.
• Cremazy F, Soullier S, Berta P, Jay P (1998). "Further complexity of the human SOX gene family revealed by the combined use of highly degenerate primers and nested PCR.". FEBS Lett. 438 (3): 311–4. doi:10.1016/S0014-5793(98)01294-0. PMID 9827568.
• Vujić M, Rajić T, Goodfellow PN, Stevanović M (1999). "cDNA characterization and high resolution mapping of the human SOX20 gene.". Mamm. Genome 9 (12): 1059–61. doi:10.1007/s003359900925. PMID 9880678.
• Miyashita A, Shimizu N, Endo N, et al. (1999). "Five different genes, Eif4a1, Cd68, Supl15h, Sox15 and Fxr2h, are clustered in a 40 kb region of mouse chromosome 11.". Gene 237 (1): 53–60. doi:10.1016/S0378-1119(99)00301-7. PMID 10524236.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.