Sp3 transcription factor

Sp3 transcription factor
PDB rendering based on 1va1.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1va1​
Identifiers
Symbols	SP3 ; SPR2
External IDs	OMIM: 601804 MGI: 1277166 HomoloGene: 7952 GeneCards: SP3 Gene
Gene ontology Molecular function • RNA polymerase II regulatory region sequence-specific DNA binding • RNA polymerase II core promoter sequence-specific DNA binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • core promoter proximal region sequence-specific DNA binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • chromatin binding • double-stranded DNA binding • protein binding • metal ion binding Cellular component • nucleus • nucleoplasm • cytoplasm • Golgi apparatus • plasma membrane • PML body • transcriptional repressor complex Biological process • negative regulation of transcription from RNA polymerase II promoter • ossification • natural killer cell differentiation • trophectodermal cell differentiation • liver development • embryonic placenta development • transcription, DNA-templated • regulation of transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • B cell differentiation • T cell differentiation • megakaryocyte differentiation • monocyte differentiation • lung development • granulocyte differentiation • enucleate erythrocyte differentiation • negative regulation of transcription, DNA-templated • positive regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • embryonic camera-type eye morphogenesis • embryonic skeletal system development • embryonic process involved in female pregnancy • definitive hemopoiesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6670	20687
Ensembl	ENSG00000172845	ENSMUSG00000027109
UniProt	Q02447	O70494
RefSeq (mRNA)	NM_001017371	NM_001018042
RefSeq (protein)	NP_001017371	NP_001018052
Location (UCSC)	Chr 2: 173.91 – 173.97 Mb	Chr 2: 72.94 – 72.98 Mb
PubMed search

Sp3 transcription factor, also known as SP3, refers to both a protein and the gene it is encoded by.

This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted.^[1]

Interactions

Sp3 transcription factor has been shown to interact with Histone deacetylase 2,^[2][3] PIAS1,^[4] E2F1^[5] and GABPA.^[6]

References

1. "Entrez Gene: SP3 Sp3 transcription factor".
2. Won, Jaejoon; Yim Jeongbin; Kim Tae Kook (October 2002). "Sp1 and Sp3 recruit histone deacetylase to repress transcription of human telomerase reverse transcriptase (hTERT) promoter in normal human somatic cells". J. Biol. Chem. (United States) 277 (41): 38230–8. doi:10.1074/jbc.M206064200. ISSN 0021-9258. PMID 12151407.
3. Sun, Jian-Min; Chen Hou Yu; Moniwa Mariko; Litchfield David W; Seto Edward; Davie James R (September 2002). "The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2". J. Biol. Chem. (United States) 277 (39): 35783–6. doi:10.1074/jbc.C200378200. ISSN 0021-9258. PMID 12176973.
4. Sapetschnig, Alexandra; Rischitor Grigore; Braun Harald; Doll Andreas; Schergaut Marion; Melchior Frauke; Suske Guntram (October 2002). "Transcription factor Sp3 is silenced through SUMO modification by PIAS1". EMBO J. (England) 21 (19): 5206–15. doi:10.1093/emboj/cdf510. ISSN 0261-4189. PMC 129032. PMID 12356736.
5. Rotheneder, H; Geymayer S; Haidweger E (November 1999). "Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter". J. Mol. Biol. (ENGLAND) 293 (5): 1005–15. doi:10.1006/jmbi.1999.3213. ISSN 0022-2836. PMID 10547281.
6. Galvagni, F; Capo S; Oliviero S (March 2001). "Sp1 and Sp3 physically interact and co-operate with GABP for the activation of the utrophin promoter". J. Mol. Biol. (England) 306 (5): 985–96. doi:10.1006/jmbi.2000.4335. ISSN 0022-2836. PMID 11237613.

Further reading

• Tseng L, Gao J, Mazella J, et al. (1997). "Differentiation-dependent and cell-specific regulation of the hIGFBP-1 gene in human endometrium.". Ann. N. Y. Acad. Sci. 828: 27–37. doi:10.1111/j.1749-6632.1997.tb48521.x. PMID 9329821.
• Zhang Y, Dufau ML (2003). "Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes.". J. Steroid Biochem. Mol. Biol. 85 (2–5): 401–14. doi:10.1016/S0960-0760(03)00230-9. PMID 12943729.