RAR-related orphan receptor beta

RAR-related orphan receptor B
PDB rendering based on 1k4w.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1k4w​, 1n4h​, 1nq7​
Identifiers
Symbols	RORB ; NR1F2; ROR-BETA; RZR-BETA; RZRB; bA133M9.1
External IDs	OMIM: 601972 MGI: 1343464 HomoloGene: 38250 IUPHAR: 599 GeneCards: RORB Gene
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • steroid hormone receptor activity • RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding • protein binding • transcription factor binding • zinc ion binding • melatonin receptor activity • sequence-specific DNA binding Cellular component • nucleus • nucleoplasm Biological process • regulation of transcription, DNA-templated • transcription initiation from RNA polymerase II promoter • G-protein coupled receptor signaling pathway • brain development • visual perception • circadian rhythm • gene expression • intracellular receptor signaling pathway • amacrine cell differentiation • eye photoreceptor cell development • regulation of circadian rhythm • steroid hormone mediated signaling pathway • negative regulation of osteoblast differentiation • negative regulation of transcription, DNA-templated • positive regulation of transcription, DNA-templated • retinal rod cell development • retinal cone cell development • retina development in camera-type eye • cellular response to retinoic acid Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6096	225998
Ensembl	ENSG00000198963	ENSMUSG00000036192
UniProt	Q92753	Q8R1B8
RefSeq (mRNA)	NM_006914	NM_001043354
RefSeq (protein)	NP_008845	NP_001036819
Location (UCSC)	Chr 9: 74.5 – 74.69 Mb	Chr 19: 18.93 – 19.11 Mb
PubMed search

RAR-related orphan receptor beta (ROR-beta), also known as NR1F2 (nuclear receptor subfamily 1, group F, member 2) is a nuclear receptor that in humans is encoded by the RORB gene.^[1]

Function

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside-diphosphate kinase involved in organogenesis and differentiation.^[2]

In the brain, ROR-beta is concentrated in layer 4 of the cerebral cortex, where it plays a role in the development of structures such as barrel columns.^[3]

Interactions

RAR-related orphan receptor beta has been shown to interact with NME1.^[4]

See also

• RAR-related orphan receptor

References

1. Giguère V, Tini M, Flock G, Ong E, Evans RM, Otulakowski G (March 1994). "Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors". Genes Dev. 8 (5): 538–53. doi:10.1101/gad.8.5.538. PMID 7926749.
2. "Entrez Gene: RORB RAR-related orphan receptor B".
3. Jabaudon D, Shnider SJ, Tischfield DJ, Galazo MJ, Macklis JD (May 2012). "RORβ induces barrel-like neuronal clusters in the developing neocortex". Cereb. Cortex 22 (5): 996–1006. doi:10.1093/cercor/bhr182. PMC 3328343. PMID 21799210.
4. Paravicini G, Steinmayr M, André E, Becker-André M (October 1996). "The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily". Biochem. Biophys. Res. Commun. 227 (1): 82–7. doi:10.1006/bbrc.1996.1471. PMID 8858107.

Further reading

• Beeson WM, Perry TW, Zurcher TD (1977). "Effect of supplemental zinc on growth and on hair and blood serum levels of beef cattle". J. Anim. Sci. 45 (1): 160–5. PMID 885817.
• Carlberg C, Hooft van Huijsduijnen R, Staple JK, DeLamarter JF, Becker-André M (1994). "RZRs, a new family of retinoid-related orphan receptors that function as both monomers and homodimers". Mol. Endocrinol. 8 (6): 757–70. doi:10.1210/me.8.6.757. PMID 7935491.
• Greiner EF, Kirfel J, Greschik H, Dörflinger U, Becker P, Mercep A, Schüle R (1996). "Functional analysis of retinoid Z receptor beta, a brain-specific nuclear orphan receptor". Proc. Natl. Acad. Sci. U.S.A. 93 (19): 10105–10. doi:10.1073/pnas.93.19.10105. PMC 38344. PMID 8816759.
• Paravicini G, Steinmayr M, André E, Becker-André M (1996). "The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily". Biochem. Biophys. Res. Commun. 227 (1): 82–7. doi:10.1006/bbrc.1996.1471. PMID 8858107.
• Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Park HT, Baek SY, Kim BS, Kim JB, Kim JJ (1996). "Developmental expression of 'RZR beta, a putative nuclear-melatonin receptor' mRNA in the suprachiasmatic nucleus of the rat". Neurosci. Lett. 217 (1): 17–20. doi:10.1016/S0304-3940(96)13060-3. PMID 8905729.
• André E, Conquet F, Steinmayr M, Stratton SC, Porciatti V, Becker-André M (1998). "Disruption of retinoid-related orphan receptor beta changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice". EMBO J. 17 (14): 3867–77. doi:10.1093/emboj/17.14.3867. PMC 1170722. PMID 9670004.
• Greiner EF, Kirfel J, Greschik H, Huang D, Becker P, Kapfhammer JP, Schüle R (2000). "Differential ligand-dependent protein-protein interactions between nuclear receptors and a neuronal-specific cofactor". Proc. Natl. Acad. Sci. U.S.A. 97 (13): 7160–5. doi:10.1073/pnas.97.13.7160. PMC 16516. PMID 10860982.
• Gawlas K, Stunnenberg HG (2000). "Differential binding and transcriptional behaviour of two highly related orphan receptors, ROR alpha(4) and ROR beta(1)". Biochim. Biophys. Acta 1494 (3): 236–41. doi:10.1016/s0167-4781(00)00237-2. PMID 11121580.
• Gawlas K, Stunnenberg HG (2001). "Differential transcription of the orphan receptor RORbeta in nuclear extracts derived from Neuro2A and HeLa cells". Nucleic Acids Res. 29 (16): 3424–32. doi:10.1093/nar/29.16.3424. PMC 55847. PMID 11504880.
• Stehlin C, Wurtz JM, Steinmetz A, Greiner E, Schüle R, Moras D, Renaud JP (2001). "X-ray structure of the orphan nuclear receptor RORbeta ligand-binding domain in the active conformation". EMBO J. 20 (21): 5822–31. doi:10.1093/emboj/20.21.5822. PMC 125710. PMID 11689423.
• Sumi Y, Yagita K, Yamaguchi S, Ishida Y, Kuroda Y, Okamura H (2002). "Rhythmic expression of ROR beta mRNA in the mice suprachiasmatic nucleus". Neurosci. Lett. 320 (1-2): 13–6. doi:10.1016/S0304-3940(02)00011-3. PMID 11849752.
• Stehlin-Gaon C, Willmann D, Zeyer D, Sanglier S, Van Dorsselaer A, Renaud JP, Moras D, Schüle R (2003). "All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR beta". Nat. Struct. Biol. 10 (10): 820–5. doi:10.1038/nsb979. PMID 12958591.

External links

• orphan nuclear receptor ROR-beta at the US National Library of Medicine Medical Subject Headings (MeSH)