Mothers against decapentaplegic homolog 5

SMAD family member 5
PDB rendering based on 1khu.
Identifiers
Symbols	SMAD5 ; DWFC; JV5-1; MADH5
External IDs	OMIM: 603110 MGI: 1328787 HomoloGene: 4313 GeneCards: SMAD5 Gene
Gene ontology Molecular function • RNA polymerase II core promoter sequence-specific DNA binding • transcription factor activity, sequence-specific DNA binding • receptor signaling protein activity • protein binding • transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity • ubiquitin protein ligase binding • metal ion binding Cellular component • intracellular • nucleus • nucleoplasm • transcription factor complex • cytoplasm • cytosol • integral component of membrane • protein complex • SMAD protein complex Biological process • ureteric bud development • Mullerian duct regression • osteoblast fate commitment • transcription, DNA-templated • protein phosphorylation • signal transduction • transforming growth factor beta receptor signaling pathway • germ cell development • embryonic pattern specification • erythrocyte differentiation • BMP signaling pathway • intracellular signal transduction • positive regulation of osteoblast differentiation • positive regulation of transcription, DNA-templated • cartilage development • cardiac muscle contraction • bone development • SMAD protein signal transduction • cellular response to organic cyclic compound • cellular response to BMP stimulus • positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4090	17129
Ensembl	ENSG00000113658	ENSMUSG00000021540
UniProt	Q99717	P97454
RefSeq (mRNA)	NM_001001419	NM_001164041
RefSeq (protein)	NP_001001419	NP_001157513
Location (UCSC)	Chr 5: 136.13 – 136.19 Mb	Chr 13: 56.7 – 56.74 Mb
PubMed search

Mothers against decapentaplegic homolog 5 also known as SMAD5 is a protein that in humans is encoded by the SMAD5 gene.^[1]

SMAD5, as its name describes, is a homolog of the Drosophila gene: "Mothers against decapentaplegic". It belongs to the SMAD family of proteins, which belong to the TGFβ superfamily of modulators. Like many other TGFβ family members SMAD5 is involved in cell signalling and modulates signals of bone morphogenetic proteins (BMP's). The binding of ligands causes the oligomerization and phosphorylation of the SMAD5 protein. SMAD5 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase. It may play a role in the pathway where TGFβ is an inhibitor of hematopoietic progenitor cells.

References

1. Riggins GJ, Thiagalingam S, Rozenblum E, Weinstein CL, Kern SE, Hamilton SR, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B (July 1996). "Mad-related genes in the human". Nat. Genet. 13 (3): 347–9. doi:10.1038/ng0796-347. PMID 8673135.